Nero/Dante/V run features the most complex playstyle. Because, each character has a different goal when it comes to their movement, combat and such. As a result, some players where they have a choice between these characters usually go for the ones that they are comfortable with rather than being optimal. This run still allows player to be creative with the methods to deal with the enemies, and a lot of room for risky strategies.
This page provides information on the character mechanics.