Griffon is a boss which encountered first in Mission 9. The actual mandatory fight starts from Mission 12 and it's final encounter in 15. It's infamously remarked that it kills the player run if:
Note: on DMD, Dante Deals 1/3 of Normal damage even in DT.
On many occasions the strategy kept changing for M12. Currently, there are 3 different approaches:
You use the Holy Water after you do any of the approaches above. The most important part of this fight is not get caught on Griffon's kite. You also need to watch out for it's lightning after death which will cost you S rank if you got hit.
For the last encounter session, you need 3 Holy Waters. The biggest issue with that fight specifically in Any% or Low% is to knock down Griffon. You will have to time and make note of the two shots:
Ideally, it's better to do these shots on DT state. Because sometimes he will have pixel hp left after popping 2 Holy Waters.
Griffon II - Maxy Punch
Griffon II - Air Raid
Griffon II - Stinger
Ideal Griffon III
Luckily for M12, there is AI manip where you can loop DT Pistol shooting. However, M15 needs a lot of work and luck. Because a well-timed meteor is the name of the fight. Example: If the attack hits the head, you are going to deal 3/4 damage. If it hits anything other than the core and head you get 1/2 damage.
Griffon 3 Start
Griffon 3 DT Build
Griffon 3 Double hit
Double Hit during Lightning Call
If you hit his critical spot so many times then griffon will fall for a short period of time. You can go after it and taunt to restore some DT Runes. However, in PS2/PS3 his chest can be exposed where you can have another opportunity to throw a meteor against it.
It's good to check the Frequently Asked Questions (FAQ) if you have general questions regarding the bosses.